Abstract: The commercial CFD software ANSYS CFX and Euler-Lagrange method were adopted in the present study to analyze the mixing performance of gas-liquid mixer by using the STT turbulence model, and the flow field and pressure drop in the mixer were obtained. The results show that the gas-liquid two-phase flow through the holes of the orifice disc enhances the interaction between fluids and promotes the mixing of gas and liquid. The pressure drop of gas-liquid two-phase flowing through the mixer increases significantly with the increasing of Reynolds number, and the local pressure drop is directly proportional to the number of the components. When Reynolds number is higher than 2.6×10⁵, the pressure drop of the two-phase flowing in the mixer is more significant.