Abstract: This paper studies the industrial innovation of enterprises in the industrial agglomeration area of Henan Province. By using the methods of field investigation, interview and network survey, it finds that factors affecting industrial innovation exist in many aspects: the government of the industrial cluster, enterprises, colleges and universities / scientific research institutes, etc. This paper divides industrial innovation into general innovation and individual innovation, and puts forward clear and operable solutions for different types of industrial innovation, hoping to provide effective intellectual support for promoting the development of industrial economy in Henan Province.