Abstract: In order to optimize the injection molding process of automobile cooling fan, this paper simulates and analyzes the injection molding process of automotive cooling fan. In the first, the force load analysis of the cooling fan is carried out with ANSYS. The stress distribution map and deformation distribution diagram of the fan are obtained. Then the mold flow analysis is performed by using Moldflow, and the DOE univariate test method is adopted. The influence of injection time on fan quality standard is analyzed and the 2D response diagram is generated. The influence factors of fan warpage deformation and the volume shrinkage rate are analyzed base on orthogonal test method. Finally, the optimal processing parameters are obtained. The results show that the stress of the cooling fan is concentrated in the middle and upper position of the fan blade, and the positional deformation is also the largest. The most reasonable injection time is 0.1 s. The influence degree of each factor on the warpage deformation is: holding pressure > mold temperature > pressure time = melt temperature and the optimal parameter combination is A1B3C3D3. The degree of influence on volume shrinkage is: melt temperature > dwell time > holding pressure > mold temperature and the optimal parameter combination is A1B2C3D2 and the optimal parameters are selected. The minimum warpage is 0.291 1 mm and the minimum volume shrinkage is 11.94%.