Abstract: This paper aims to investigate the impact of vortex generator application on cavitation within a high-speed liquid oxygen pump. Due to the limitations of traditional cavitation control methods in enhancing the cavitation performance of high-speed liquid oxygen pumps effectively, this paper proposes a cavitation control strategy based on vortex generators for high-speed pump applications. Builded on previous research on water wing cavitation control, numerical simulation methods were employed to analyze the effects of different vortex generator placement methods on the pump's erosion resistance. The research results demonstrate that vortex generators can reduce the dissipative losses caused by turbulent fluctuations, but their influence on cavitation varies depending on their specific positions. By identifying the optimal placement of vortex generators, it was found that positioning them at 120° and 150° from the leading edge achieves better erosion resistance performance. At these positions, the cavitation volume within the impeller, as well as the vortex intensity, are significantly reduced, which leading to a decrease in the NPSHc. The findings of this study provide valuable insights for cavitation control in high-speed liquid oxygen pumps.