ObjectiveTo investigate the effect of shengmaisan prescription granule and it's modified prescription on the anti-stress ability.

MethodsThe mice were randomly divided into 5 groups: The blank control group, HJT group(positive control group), shengmaisan group, yiqi shengmaisan group, huoxue shengmaisan group. All groups were intragastrically given the drugs for seven consecutive days once per day. Then the swimming time under burden, the time of hypoxia tolerance under normal pressure, the survival time after being poisoned by sodium nitrite, the gasping time after being cut head and the survival rate in cold environment were compared between the five groups.

Resultsshengmaisan prescription granule and it's modified prescription prolonged the time of swimming and hypoxia tolerance, and improve the survival rate under cold environment in mice. Compared with shengmaisan prescription granule, huoxue shengmaisan improved the ability of hypoxia tolerance, and yiqi shengmaisan improved the ability of cold-resistance in mice significantly.

Conclusionshengmaisan prescription granule and it's modified prescription have anti-stress function. shengmaisan prescription granule has stronger action on hypoxia tolerance and cold-resistance after adding salvia formula granule and Astragalus formula granule, respectively.