Abstract: Modification and optimization of natural compounds with higher activity in botanic pesticides are important directions in the field of pesticides. In this paper, four novel gallic acid derivatives were synthesized through the formation of protecting group, acylation, deprotection reaction with the gallic acid as the raw material. The final products were confirmed by ¹H NMR, ¹³C NMR and HRMS. In addition, the antibacterial activities of four compounds on Ahernaria mali, Physalospora Piricola, Rhizoctonia solani and Phytophthora infestans were studied.