Abstract: Information security plays an important role in the construction and service of smart library in colleges and universities.Taking the informatization construction of smart library of Yunnan Normal University as an example, this paper expounds the information security system construction of university smart library from two aspects: information security technology and information security management system construction.From traditional information security protection such as next-generation application firewalls, Web application firewalls, online behavior audit, VPN technology, bastion host, vulnerability scanning system, situation awareness system based on security big data analysis such as endpoint detection and response platform, security situation awareness platform, and in accordance with the relevant laws and regulations of national information security, real-name authentication, software legalization and information security level protection are constructed, reverse proxy and Website group management system which can effectively enhance security, design and construction of information security system from above aspects. It has important practical significance and reference significance for the information security system construction of the similar smart libraries of colleges and universities in China.