How to use the “enclave economic model” to realize the mutual benefit and sustainable development in the process of constructing inter-regional horizontal ecological compensation mechanism is a new problem that needs to be solved urgently. This paper firstly defines the concept of “enclave economy”, expounds the positioning of “enclave economy” in the strategy of horizontal ecological compensation mechanism. Then, it introduces a diversified government objective function including economic, ecological, resource and social indicators to ensure sustainable operation of “enclave economy model” with fuzzy mathematics tools, and quantifies government objective function value to achieve mutual benefit and win-win. Finally, it summarizes the basic conditions for achieving the mutual benefit and sustainable development of the “enclave economy” model. On this basis, it puts forward the following countermeasures: taking local advantages, persisting in institutional mechanism innovation, standardizing government behavior, strengthening top-level design, and combining incentive and restrictive systems.