How to scientifically calculate the remediation potential and remediation strategy of rural residential land under the "third lines" demarcation context is the key measure to implement the control of land space use and optimize the allocation of land resources. This paper uses population prediction and potential measurement model to classify and define the potential source and regulation flow direction on the basis of coordination theory of man-land relationship. The results show that according to the defined areas and regulation guidance of the "three lines", the regulation strategies are divided into three types: ecological development, agricultural land security and urban-rural overall planning. Among them, the remediation potential under ecological development is relatively small, and the focus should be to promote the remediation of ecological land, enhance regional ecological functions and ensure regional ecological advantages. The regulation potential is large and involves a wide range under agricultural land regulation, the key is to promote agricultural land reclamation and ensure regional agricultural production. The remediation potential under urban-rural overall planning is small, reasonable guidance should be the spatial layout structure of rural residential land, so as to lay a foundation for realization of the goal of regional land intensification.