This study is based on the comparison between the theoretical standards of the comprehensive health concept's nature and the anti-healthy condition derived from the principle of comprehensive health treatment. The Dezhi principle of comprehensive health treatment is introduced and there are altogether eight types of diseases concluded. They are predictable disease, potential disease, existing disease, severe disease, recovering disease, repeated disease, kind-treated disease and self-treated disease. According to the generalized disease location, course of disease, disease degree and pathological change, the anti-healthy or pathological condition is defined. And their causes are revealed by the pathogen root, etiology and disease pathogenesis at different levels of ecosystem balance-unbalanced-balance. Then the comprehensive treatment strategies are proposed. Finally, the paper verifies the effectiveness of China's actions in fighting against COVID-19 with Chinese strategies, and proves the correctness of the eight pathologies treatment in line with the concept of comprehensive health. Through the application of the principle of comprehensive health treatment, this paper not only makes an argument on the concept of the unity of nature and human being, the integration of body and mind in the field of Chinese Medicine, but also infers that the eight spirits, eight wills, eight emotions, eight ethics, eight kinds of belief and eight kinds of fair, so as to form the pathway and mechanism of nourishing the internal organs, protecting heart and keeping the comprehensive health of four living states, four hearts, good relationship between mind and body .