Information construction is an important content and key field in the construction of medical consortia. At present, medical consortia information construction faces some problems: medical information data is difficult to share, medical privacy data is easy to leak, and medical data quality is hard to change. By studying the technical principles and characteristics of the blockchain, the paper points out that the blockchain technology has a high degree of compatibility with the information construction of the medical consortia and close interaction between doctors and patients in an intelligent way to ensure the efficient data sharing, and strengthen data security governance, and improve data accuracy, consistency, timeliness and regularity. Therefore, it is feasible to embed the blockchain technology into the medical consortia information construction. However, there are still many challenges in technology, concept, supervision and other aspects when blockchain technology is applied to the information construction of medical consortia. It is necessary to improve the technology application methods, change the concept mode of the medical prescription, and improve the regulatory supervision system in the future.