Information organization based on theme map and precise information service mode play an important role in offering personalized, intelligent and fast and accurate medical and health information service. On the basis of understanding the current situation of organization, utilization and service of medical health information at home and abroad, this paper constructs a theme map of medical health information in accordance with the difference in mastery of medical health information between the public and doctors. The theme map forms a corresponding relationship between professional terms and localized expressions, which is convenient for the public to understand and master health information. The paper also proposes a precise information service mode which automatically matches the symptoms described by patients with disease data base, in order to improve the diagnosis of diseases by grass-roots doctors. Taking hepatitis B as an example and by using the experimental simulation method, this paper constructs a theme map of hepatitis B, and an accurate diagnosis simulation of hepatitis B. The results show that the organization of medical health information based on theme map can not only improve the quality of doctor-patient communication, but also improve the general public's health literacy.