Abstract: There is no doubt that "Sanyan" has its own uniqueness in the novels of the Ming Dynasty. Previous research predominantly focused on the ideological theme, author's ability, textual research and communication influence. However, from the perspective of disease and treatment, the works related to Taoism in "Sanyan" are a new breakthrough Taoism, as a native religion in China, has its special cultural soil and growth conditions. This strong life consciousness and longevity thought rooted in Chinese culture make the works build a world with therapeutic effect on both mental and physical diseases The novel exhorts the world to abandon the partition of material desires and achieve the role of cleaning the mind and nature; Use Taoism to achieve social relief and complete the treatment of physical diseases; Realize the cure of mental pain points with the help of dreams. At the same time, through narration, disease and treatment play an important role in generating the plot of the novel and expanding the theme of characterization. In this sense, "Sanyan" is a rare model.